Physician-Formulated Brain Wellness

Backed by 15+ years of clinical ingredient data and developed with leading physicians, Awake Brain Wellness supports focus, memory, and mental clarity through your body's natural methylation cycle. No stimulants. No proprietary blends. Just clean, evidence-backed ingredients that work.

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Nearly 30% of Americans 18–65 deal with brain fog, memory issues, and cognitive decline. Most cases trace back to nutritional deficiencies and methylation problems. Awake supports the foundation, not just the symptoms. With four clinically studied ingredients in one daily capsule.

How it Works

Awake was developed with input from Dr. Adi Iyer and naturopathic doctor Janet Zand, drawing on decades of clinical experience in brain health and integrative medicine. Dr. Iyer completed his neurosurgery residency and interventional neuroradiology fellowship at Stanford University. A formula built at the intersection of clinical neuroscience and nutritional science.

Meet our Team

Awake Therapeutics

Awake Brain Wellness

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How Awake Works

01

Restore the Cycle

L-5-MTHF Folate is the bioactive form your body uses right away. Together with Trimethylglycine, it supports your methylation cycle, the engine behind neurotransmitters like serotonin, dopamine, and acetylcholine, the one most closely tied to memory. Methylfolate also supports healthy nitric oxide production and blood flow.

02

Protect the Brain

Methylcobalamin is the active, body-ready form of vitamin B12. It plays a key role in the methylation pathways that support healthy nerve and brain function, and in the body's normal production of myelin, the protective layer that surrounds your nerves.

03

Support Under Stress

Trimethylglycine acts as a methyl donor through an alternative pathway, keeping homocysteine levels in check even when your body is under stress. Elevated homocysteine is linked to long-term cognitive decline.

The Science

Five pathways your brain depends on

Awake Brain Wellness is built around the nutrients that support how your brain makes energy, clears waste, and stays connected.

1

Supports Acetylcholine Production

Bioactive folate plays a role in the methylation pathways involved in neurotransmitter production. Acetylcholine is one of the signals your brain uses for memory and learning.

2

Supports Glutathione Production

NAC is a precursor to glutathione, one of the body's primary antioxidants. Glutathione helps the body manage everyday oxidative stress.

3

Supports Healthy Blood Flow

Bioactive folate has been studied for its role in supporting endothelial function, which is how blood vessels stay flexible and responsive.

4

Supports Cellular Maintenance

Methylcobalamin, the active form of B12, plays a role in myelin production and the ongoing maintenance of healthy nerve cells.

5

Supports Healthy Homocysteine Metabolism

Trimethylglycine works as a methyl donor alongside folate and B12. Together they support the body's normal homocysteine metabolism, a marker tied to long term brain wellness.

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Every Ingredient Earns Its Place

No caffeine. No proprietary blends. No artificial additives or preservatives.

5 mg

L-5-MTHF Folate

Bioactive Folate

The form of folate your body can readily use, bypassing the MTHFR genetic bottleneck that affects nearly half the population. Supports healthy homocysteine and the nitric oxide production behind blood flow to the brain.

1 mg

Methylcobalamin B12

Active Vitamin B12

The methylated, neurologically active form of B12. It works with folate to support neurotransmitter production, sustained cognitive energy, and the formation of myelin, the protective sheath that keeps nerve signals fast and clear.

500 mg

NAC

N-Acetyl-L-Cysteine (Vegan)

A powerful precursor to glutathione — your brain's primary antioxidant defense. Supports detoxification pathways and helps protect neurons from oxidative stress.

100 mg

Trimethylglycine

TMG

A methyl donor that supports an alternative methylation pathway, helping your body maintain optimal homocysteine metabolism and cellular function even under stress.

Dr. Adi Iyer

Board-Certified Neurosurgeon

At Stanford University, Dr. Iyer completed his neurosurgery residency and interventional neuroradiology fellowship, with training centered on brain structure and neurological function, conditions affecting cognition and the central nervous system, and advanced clinical and surgical approaches to brain health.

Dr. Janet Zand

Integrative Medicine Practitioner & Nutrition Expert

Over 30 years of experience in natural health. Co-author of Smart Medicine for a Healthier Child. Focuses on nutrition-based health support, herbal and supplement-based approaches, and root-cause wellness strategies.

25+

Years of supplement manufacturing expertise behind our formulations

100%

Ingredient transparency | Every dosage published, nothing hidden

Thousands

of patients supported through physician-directed use before our consumer launch

Transparency Is the Standard

Tested. Verified. Trusted.

✓

GMP Certified

🔬

Lab Tested

🌱

Vegan

🚫

Gluten Free

🇺🇸

Made in USA

Every batch is tested for purity, potency, and contaminants. We publish exactly what's in the capsule because you should know what you're putting in your body.

Ingredients Over Claims.

The brain health market is full of proprietary blends, underdosed formulas, and marketing that overpromises. Awake exists because we believe you deserve to know exactly what you're taking, and that every ingredient should be there because of research, not trends. Four ingredients. Full dosages. Nothing to hide.

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What Our Customers Say

Individual results may vary. These testimonials reflect personal experiences and are not a guarantee of results.

Carter E.

Student, Gym Enthusiast

I can tell the difference. I'm not heading to the fridge for ketchup and blanking on what I came for.

Sandra F.

Businesswoman

My husband used it for a long, long while. He was nearly 75 and sharp as a tack, and that's why I believe in it.

Megan M.

Full-time Mom

I would forget things all the time and it was awful... I'd cry out of frustration. There's still a little, but it's nowhere near how bad it used to be.

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The Backbone

Built Long Before the Brand.

Every Awake product is manufactured by a team with over 25 years of experience in supplement development. That means pharmaceutical-grade manufacturing standards, vetted ingredient sourcing, and formulations built on decades of real-world results. When your brain health is on the line, the people making the capsule matter as much as what's inside it.

Your Mind, Fully Awake

Built on Science, Not Hype

Made by Trusted Doctors